Disabling a replicated suffix removes it from the replication topology. It will no longer be updated or send updates, depending on its role as a master, hub, or consumer. Disabling a suffix on a supplier server deletes all replication agreements, and they will have to be re-created if the replica is enabled again.
You can use DSCC to perform this task. For information, see Directory Service Control Center Interface and the DSCC online help.