If you modify any of the configuration files manually, you must restart the i-Planet gateway's reverse proxy server for it to recognize the changes. It is generally a good idea to first stop the reverse proxy, to ensure that it is not running, then to restart the reverse proxy.
Restarting the reverse proxy on the i-Planet gateway should not affect an application, if it is not using a Netlet other than the time it takes to restart the reverse proxy server on the i-Planet gateway. Any connection through the Netlet will be lost when you restart the reverse proxy server.
If you have to reboot the i-Planet gateway, the reverse proxy server will start automatically.