For sufficient accuracy, set the number of simulation trials to the minimum number necessary to obtain a reliable estimate of the statistic being optimized. For example, you can reliably estimate the mean with fewer trials than the standard deviation or a percentile.
General guidelines for determining the number of simulation trials necessary to obtain good estimates are:
Empirical testing with the simulation model using the Crystal Ball Bootstrap tool (see the Oracle Crystal Ball User's Guide) can help you find the appropriate number of trials for a given situation.