Associate a symptom with the diagnosis

Click the up or down arrows to associate a selected symptom with a diagnosis. In Argus Safety, select the symptom and click Move Up or Move Down.

For the example:

Defining a diagnosis-event relationship can clarify an adverse event report. Suppose an initial case report describes a patient suffering from Somnolence, Sore Throat, and Fever.
AE #     Diagnosis AE Term (Associated AEs)
 1           Somnolence 
 2           Sore Throat
 3           Fever
For reports on all events, they would appear on a CIOMS-I form as:

• Somnolence [SEDATION]
• Sore Throat [SORE THROAT NOS]
• Fever [PYREXIA]

Suppose a Follow-up report then supplies information that the patient also had neutropenia, and had been diagnosed as suffering from agranulocytosis (the cause of the sore throat and fever). The somnolence was considered to be coincidental, and unrelated to any other adverse events.
Neutropenia and agranulocytosis would be entered into the system, and a diagnosis-event relationship established as follows:

AE #	Diagnosis AE Term (Associated AEs)
1	Yes agranulocytosis
2	(sore throat)
3	(fever)
4	(neutropenia)
5	Somnolence

These events would appear on a CIOMS I form as:

• AGRANULOCYTOSIS
• [AGRANULOCYTOSIS] [SORE THROAT],
• [PYREXIA NOS], [NEUTROPENIA]
• Somnolence [SEDATION]

This immediately provides a clear clinical picture of the case.