Step 4 for logistic regression runs: Select the events and specify drugs

When defining a logistic regression run, you specify values (that is, responses) for the event variable that you are investigating with the run on the Select Event page. Oracle Empirica Signal computes separate results for each specified event value.

Oracle Empirica Signal computes values for an event only if it finds a sufficient number of reports. Results are not produced for an event if either of the following situations exists:

• For all drugs explicitly included in the run no reports are found with the event and, in addition, the drugs that do occur in combination with the event most frequently do not meet the specified minimum number of occurrences for inclusion. (For more information on specifying drug values see Specifying drugs for logistic regression.)
• For the covariate variables selected for the run, the number of reports that include the event and each of the possible covariate values averages less than 10. This is determined as follows:

  10 * the total number of possible values for all covariate variables that occur with this event > count of reports for the event.

If an event is specified for the run but results are not produced, one of these reasons appears in the logistic regression log file produced for the run.

If you specify a single event and that event is not found in the data used in the run, the run fails and an error appears on the Jobs for Run page. If you specify multiple events and any one of them is not found, the run fails and a message appears in the error log. You can access the logistic regression log file and the error log from the Job Detail page.

Typically, logistic regression data mining runs do not include every possible drug+event combination. Instead, they are generally used to focus on specific medically related adverse events (response values) and drugs of interest (predictors). For some investigations, you may wish to compute scores for all adverse events in the selected data configuration (after database restrictions are applied).

Note:

When selecting events, keep in mind that there is a logistic regression computation for each response value. The more events you select as responses, the longer the LR run takes

1. In the left navigation pane, hover on the Data Analysis icon (), then click Data Mining Runs.
2. At the top left of the Data Mining Runs home page, click Create Run.
3. On the Create Data Mining Run page, select the type of run to create and click Next.
4. On the Select "As Of" Date page, choose the latest date and time or select Other to choose a date and time. Then click Next.
5. On the Select Variables page, select an event variable and a drug variable. Include additional covariates and define a custom term if you want, then click Next.
6. On the Logistic Regression: Select Events page, select the Select all available values check box to include all of the events in the configuration in your run, type the events in the text box, or select events using the links to the right of the (Event) HLGT box.
7. Click Next to open the Logistic Regression: Select Drugs page, and continue with specifying drug values.
8. Read the description of the events you selected and accept or change the values shown for the model.
9. Specify the (Drug) Product Family Name by typing it in the text box or selecting using the Select Available Values and Select Saved List links.
10. (Optional) Select the Compute interactions check box to include drug interactions.
11. Click Next to define the run options.