Upgrade Cloned Databases
If you have cloned a database, see Cloning Oracle Clinical and TMS 4.6.x, 5.0.x, 5.1.x, 5.2.x and 5.4.x Databases (Document ID 883213.1) on My Oracle Support.
Be sure to follow all the instructions in the document, including running the tmschown.sql script, the opachown.sql script, and, if you are using Oracle Clinical with TMS, the occhown.sql script, before doing the upgrade.