How do I specify the size of the blocks in my randomization list to prevent unblinding?

You specify a multiplier that is used to calculate the number of randomization numbers in each block in the randomization list. Oracle Clinical One Platform adds the numbers in a treatment ratio and multiplies the sum by the multiplier.

For example:

• For a 1:2 ratio, the sum is 3 (1 + 2 = 3).
• For a multiplier of 4, the block size is 12 (3 x 4 = 12).

We recommend that you use a multiplier of 2 or higher to prevent unblinding.