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Example—SignatureDef

<SignatureDef OID="CRA Sigs" Methodology="Electronic">

<Meaning>Approved</Meaning>

<LegalReason>

By my dated signature below, I, %s %s, verify that this case report form accurately displays the results of the examinations, tests, evaluations and treatments noted within. Pursuant to Section 11.100 of Title 21 of the Code of Federal Regulations, this is to certify that I intend that this electronic signature is to be the legally binding equivalent of my handwritten signature. To this I do attest by supplying my password and clicking the button marked Submit below.

</LegalReason>

</SignatureDef>

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