Some of the common objects that appear in the administration GUI are automatically saved when they are edited or new objects are added. You do not need to save these objects. Once these objects are added or edited, the change applies immediately and is not revertible. The reason the Save button in the administration GUI does not become active when you alter these is because there is no in-memory buffer of unsaved changes.
Although the changes made to these objects are saved immediately, they do not (except for logmacro) take effect until the next activation. The administration GUI edits Authorized Users, which are authuser objects, Proxy Users, which are proxyuser objects, and Jar Signatures and Jar Hashes, which are both vars objects.
Common Objects with this behavior are:
Authorized User
Admin User
Jar Signature
Jar Hash
Proxy User