Nested confidence interval graph (Drug Profile page)

To help you investigate possible drug interactions, the nested confidence interval graph displays sets of confidence intervals. In each set, the first confidence interval is for the three-way combination of drug, drug, and event, and subsequent confidence intervals are for the two-way combinations. In each confidence interval bar, the EB05 value is at the left end, the EBGM value is the dot on the bar, and the EB95 value is at the right end. A confidence interval bar is highlighted if its INTSS value is greater than the limit that you specify as a display option. For more information about INTSS, see interaction scores.

To conserve space in labeling, the drug indicated in the title bar of the graph window is referred to by the label "Drug" in the graph.

The key below the graph indicates INTSS values represented by the confidence interval bars.

1. To set options for the graph, click Options. Specify the following options and click OK. The options apply to the specific chart, and are saved as part of the layout.

   Option	Description
   N at least	Display only those drug-drug-event combinations with an observed count (N) of at least the specified number.
   At most _____ combinations	Display no more than the specified number of drug-drug-event combinatoins. You can display graphs for up to 200 combinations. If combinations are excluded because of this limit, a message appears below the graph.
   Order by	The value of the score that you select here for the drug-drug-event combinations is used to sort the graphs. For example, if your select INTSS, the graph with the highest INTSS value for the drug-drug-event combination appears first.
   Axis Type	Select either Linear or Log (logarithmic). When you use a logarithmic axis, the confidence intervals for the two-way combinations may appear more clearly.
   Highlight confidence intervals where INTSS >	Enter the INTSS value above which confidence interval bars will be highlighted.
   Show N at end of confidence interval	Display the value of N at the end of each bar
   Use gray-scale instead of colors	Use shades of gray instead of colors in the graph.

2. You can point to a line in the graph to display statistics for the combination represented by the line. Long drug or event terms may end in an ellipsis in the label on the graph itself; in this case, you can point to the line to see the full terms.
3. If you click on a bar, you can then drill down to a list of cases for the bar, create a case series, transfer to case series, download cases, download case details, or run reports for those cases.