MySQL Server can accept TCP/IP connections from clients connecting over IPv6. For example, this command connects over IPv6 to the MySQL server on the local host:

$> mysql -h ::1

To use this capability, two things must be true:

MySQL account names permit IPv6 addresses to enable DBAs to specify privileges for clients that connect to the server over IPv6. See Section 8.2.4, “Specifying Account Names”. IPv6 addresses can be specified in account names in statements such as CREATE USER, GRANT, and REVOKE. For example:

mysql> CREATE USER 'bill'@'::1' IDENTIFIED BY 'secret';
mysql> GRANT SELECT ON mydb.* TO 'bill'@'::1';

IPv6 functions enable conversion between string and internal format IPv6 address formats, and checking whether values represent valid IPv6 addresses. For example, INET6_ATON() and INET6_NTOA() are similar to INET_ATON() and INET_NTOA(), but handle IPv6 addresses in addition to IPv4 addresses. See Section 14.23, “Miscellaneous Functions”.

From MySQL 8.0.14, Group Replication group members can use IPv6 addresses for communications within the group. A group can contain a mix of members using IPv6 and members using IPv4. See Section 20.5.5, “Support For IPv6 And For Mixed IPv6 And IPv4 Groups”.