Sector map graph (Drug Profile page)

A sector map is a visual presentation of data for a selected drug across all System Organ Classes (SOCs). Each System Organ Class (SOC) is represented by a large tile in the sector map. Smaller tiles within each SOC tile represent Preferred Terms (PTs).

PTs are ranked in descending order of values of the statistic (EBGM, EB05, Chi-statistic, or PRR) that you choose. A color key indicates relative ranking. You can also list the ranked PTs below the sector map. (You must include the key in the graph to display both the color key and the list of ranked PTs.)

Note:

The primary path of a PT determines where it appears in the sector map. If a PT is not in the event hierarchy associated with the data mining run results, it appears in a SOC tile named Unknown.

The list of ranked PTs below the sector map includes the following information:

Column	Description
Rank	Ranking of the term (combined with the drug) according to values of the statistic you have configured the sector map to use (via the Color controlled by option).
SOC	SOC containing the term.
Term (PT)	Specific PT.
EBGM. EB05, ERAM, ER05, Chi-statistic, or PRR	Value of the statistic you have configured the sector map to use (via the Color controlled by option).

1. To set options for the graph, click Options. Specify the following options and click OK. The options apply to the specific chart, and are saved as part of the layout.

   Option	Description
   Color controlled by	Name of the statistic whose values will be ranked and used for coloring the sector map tiles. Available values are those computed by the data mining run and may include EBGM, EB05, Chi-statistic (signed), and PRR.
   Term box size controlled by	One of the following options indicating what controls the size of PT tiles: Relative importance of term—Bases the size of PT tiles on an algorithm that determines the relative public heath impact of PTs. Using a recent version of AERS data, the public health impact for a PT is computed as: (number of times the PT occurs in serious cases) * (proportion of cases with that PT that are serious or fatal). A higher Public Health Impact score corresponds to a larger tile in the sector map. Because size is based on the number of cases of the PT alone (not the number of cases that have the PT and a particular drug), the tile size is stable over sector maps for different drugs. All terms have equal size—All PT tiles have the same size. Note: For PTs that are new in the MedDRA version associated with the AERS data used to assess public health impact, the tile size cannot be determined. Such PTs are represented as small tiles.
   Display maximum intensity at signal score of	All tiles for which scores are above this value are displayed at the maximum-intensity color as shown in the color key below the graph.
   Use gray-scale instead of colors	Use shades of gray instead of colors in the graph.
   Show low scores in green for color graph	Check to show low scores in varying shades of green. Clear to show low signal scores in black. Note: This setting has no effect if you display the sector map in gray-scale.
   Omit rare terms used fewer than __ times in AERS	Number indicating how many times a PT must be in the AERS database (the same one used for Relative importance of term) for that PT to be shown in the sector map. Note: The notes for a sector map indicate any rare terms that are omitted because of this restriction.
   Group by HLT	Within a SOC tile, group in the same rectangular area the tiles for PTs that are in the same HLT. If you also group by HLGT, the tiles for PTs are grouped by HLT within each HLGT.
   Group by HLGT	Within a SOC tile, group in the same rectangular area the tiles for PTs that are in the same HLGT.
   List __ top scores	Number indicating how many (up to 1000) terms with the top scores are ranked and listed below the sector map. The score is the statistic selected for Color controlled by. If multiple terms have the same score, each term is counted separately. For example, suppose that you enter 20 as the limit. If the 20th row has a score that other terms after that also have, those additional terms are shown as well. The list below the sector map appears when you display the key.
   Show top score indexes	If checked, tiles in the sector map are numbered to show their rank, up to the number of scores specified in List __ top scores. For this option to take effect, there must be a value specified for List __ top scores".

2. If you point to a PT tile, the MedDRA PT, HLT, HLGT, and SOC appears. The following information for the combination of the drug and the term that the tile represents also appears:
   • N—Observed number of cases with drug-event combination.
   • EBGM—Empirical Bayesian Geometric Mean. A more stable estimate than RR; the so-called shrinkage estimate.
   • EB05—A value such that there is approximately a 5% probability that the true Relative Ratio lies below it.
   • ERAM—Empirical-Bayes Regression-adjusted Arithmetic Mean. This estimate is computed as the shrunken observed-to-expected reporting ratio adjusted for covariates and concomitant drugs.
   • ER05—A value that there is approximately a 5% probability that the ERAM lies below it.

     Note:

     The ERAM and ER05 are available only if the data mining run was set up to compute RGPS.
   • PRR—Proportional Reporting Ratio.
   • Chi-statistic—Chi-statistic associated with PRR. (If EBGM < 1, the Chi-statistic is expressed as a negative number, indicating that the drug-event combination is more rare than expected). The Chi-statistic is the signed square root of Chi-square.

     Note:

     The PRR and Chi-statistic are available only if the data mining run was set up to compute PRR.

   For information about these statistics, see MGPS computations or PRR computations.

3. To zoom in on a particular SOC, click anywhere on the SOC tile and select Zoom from the menu that appears.
4. If you click a tile for which N is at least 1, you can then drill down to a list of cases for the tile or view statistics for the tile.